Cytosolic calcium in platelet activation |
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Authors: | T. J. Rink |
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Affiliation: | 1. Smith Kline & French Research Ltd, The Frythe, AL6 9AR, Welwyn, Hertshire, (England)
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Abstract: | Experiments with permeabilised platelets, and with intact platelets loaded with fluorescent Ca2+-indicators, over the past several years have greatly extended our knowledge and understanding of cytosolic Ca2+ as a platelet activator and its interactions with other cytosolic regulators. This article outlines insights, gained from the use of the fluorescent dyes, into maintenance and restoration of basal [Ca2+]i, mechanisms of receptor-mediated Ca2+-mobilisation and quantitation of [Ca2+]i/response relations in intact human platelets. |
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Keywords: | Calcium platelet second messenger |
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