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Gui-Pi-Wan extract acts as a radioprotective agent |
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| Authors: | Ping Xu EnJin Jiang |
| Institution: | (1) Key Laboratory of Molecular Epigenetics of Ministry of Education, Northeast Normal University, Changchun, 130024, China;(2) Department of Agronomy, Jilin Agricultural University, Changchun, 130118, China;(3) Changchun University of Chinese Traditional Medicine, Changchun, 130021, China;(4) Baihua Ginseng Cooperation Ltd, Shanghai, 200010, China; |
| Abstract: | The radioprotective effects of 6 Gui-Pi-Wan extracts were investigated by examining cell viability and 30-d survival of mice after total-body 60Co irradiation. Pretreatment with Gui-Pi-Wan precipitate by water extraction and alcohol precipitation (PWA) prior to irradiation resulted in significantly higher cell survival and lower apoptosis rates at 24 h after 5 Gy radiation, and increased 30-d survival in mice after exposure to a potentially lethal dose of 8 Gy. These results collectively indicate that PWA of Gui-Pi-Wan extracts is an effective radioprotective agent. |
| Keywords: | Gui-Pi-Wan PWA cell survival apoptosis rate survival rate |
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