| Fe3O4/SiO2/石墨烯-CdTe量子点/CS纳米复合材料对smcc-7 721细胞的毒性研究 |
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| 引用本文： | 黄岚珍,胡炎炳,郎海洋,欧俊.Fe3O4/SiO2/石墨烯-CdTe量子点/CS纳米复合材料对smcc-7 721细胞的毒性研究[J].科学技术与工程,2018,18(12). |
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| 作者姓名： | 黄岚珍 胡炎炳 郎海洋 欧俊 |
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| 作者单位： | 桂林医学院,桂林理工大学,桂林理工大学,桂林理工大学（Guilin University of Technology） |
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| 基金项目： | 国家自然科学基金（51362006） |
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| 摘 要： | 研究磁性Fe3O4/SiO2/石墨烯-CdTe量子点/脱乙酰壳多糖纳米复合材料(FGQCs)提高药物传输效率的潜力。通过MTT法检测细胞活力,相差倒置显微镜观察给药后的细胞生长形态,流式细胞仪检测药物载体混悬液(5-FU-FGQCs)对smmc-7 721细胞增殖的影响。实验结果表明,FGQCs具有良好的生物相容性,5-FU-FGQCs具有更高的药物输送效率证明FGQCs增强了5-FU药物的细胞毒性。
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| 关 键 词： | FGQCs 药物传输效率 生物相容性 细胞毒性 |
| 收稿时间： | 2017/10/20 0:00:00 |
| 修稿时间： | 2018/1/7 0:00:00 |
Toxicity of Fe3O4/SiO2/graphene-CdTe Quantum Dots/CS Nanocomposites on smcc-7 721 Cells |
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| Huang lanzhen,Hu yanbing,Lang haiyang and.Toxicity of Fe3O4/SiO2/graphene-CdTe Quantum Dots/CS Nanocomposites on smcc-7 721 Cells[J].Science Technology and Engineering,2018,18(12). |
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| Authors: | Huang lanzhen Hu yanbing Lang haiyang and |
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| Institution: | Guilin Medical University,Guilin University of Technology,Guilin University of Technology, |
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| Abstract: | To study the potential of magnetic Fe3O4/SiO2/graphene-CdTe quantum dot/chitosan nanocomposite (FGQCs) to improve drug delivery efficiency. MTT assay was used to detect the cell viability, and the cell growth morphology was observed by contrast microscope. The effect of 5-FU-FGQCs on the proliferation of smmc-7721 cells was detected by flow cytometry. The results showed that FGQCs had good biocompatibility, and 5-FU-FGQCs had higher drug delivery efficiency to demonstrate that FGQCs could enhance the cytotoxicity of 5-FU drugs. |
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| Keywords: | FQDCs drug delivery efficiency biocompatibility cytotoxicity |
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