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Sequential proteome alterations during genesis and progression of colon cancer |
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| Authors: | U. J. Roblick D. Hirschberg J. K. Habermann C. Palmberg S. Becker S. Krüger M. Gustafsson H.-P. Bruch B. Franzén T. Ried T. Bergmann G. Auer H. Jörnvall |
| Affiliation: | (1) Department of Oncology and Pathology, Unit of Cancer Proteomics, Karolinska Institutet and Hospital, 171 76 Stockholm, Sweden;(2) Department of Surgery, Campus Lübeck Medical School, University of Schleswig-Holstein, Lübeck, Germany;(3) Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden;(4) Department of Genetics Branch, NIH Center for Cancer Research, NCI/NIH, Washington, Bethesda Maryland, USA;(5) Institute of Pathology, University of Lübeck, Medical School, Lübeck, Germany;(6) Gyros AB, Uppsala Science Park, 751 83 Uppsala, Sweden;(7) Astra Zeneca AB, Preclinical R&D, 151 85 Södertälje, Sweden |
| Abstract: | Changes in the proteome of colon mucosal cells accompany the transition from normal mucosa via adenoma and invasive cancer to metastatic disease. Samples from 15 patients with sporadic sigmoid cancers were analyzed. Proteins were separated by two-dimensional gel electrophoresis. Relative differences in expression levels between normal tissue, adenoma, carcinoma and metastasis were evaluated in both intra- and inter-patient comparisons. Up- and down-regulated proteins ( |
| Keywords: | Proteomics 2-D gel electrophoresis mass spectrometry tumor marker colon cancer |
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