Biological functions and signaling of a transmembrane semaphorin,CD100/Sema4D |
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Authors: | A?Kumanogoh Email author" target="_blank">H?KikutaniEmail author |
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Institution: | (1) Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, 565-0871 Osaka, Japan |
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Abstract: | The semaphorin proteins were identified originally as axonal guidance factors functioning during neuronal development. In addition to this function, several semaphorins play diverse roles outside the nervous system. The class 4 semaphorin CD100/Sema4D, which utilizes plexin-B1 and CD72 as receptors, exerts important biological effects on a variety of cells, including the neuronal, epithelial and immune cells. Here, we review recent advances exploring the molecular mechanisms governing the biological functions of CD100/Sema4D.Received 1 July 2003; received after revision 25 July 2003; accepted 29 July 2003 |
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Keywords: | CD100/Sema4D semaphorin plexin-B1 CD72 Met SHP-1 |
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