| （R）－2－甲基－1，4－丁二醇及其衍生物的合成研究 |
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| 引用本文： | 李焰,潘贻军,张万轩,黄锦霞,徐章煌. （R）－2－甲基－1，4－丁二醇及其衍生物的合成研究[J]. 湖北大学学报(自然科学版), 1996, 0(3) |
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| 作者姓名： | 李焰 潘贻军 张万轩 黄锦霞 徐章煌 |
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| 作者单位： | 湖北大学化学系 |
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| 摘 要： | 手性２－甲基－１，４－丁二醇及其衍生物是合成各种手性近晶型液晶材料以及手性天然生物活性物质的重要中间体，以３－甲基－３－丁烯－１－醇为原料利用改进的不对称硼氢化－氧化反应，成功地合成了（Ｒ）－２－甲基－１，４－丁二醇以及其２种手性衍生物：（Ｒ）－２－甲基－４－四氢吡喃氧基－１－醇和（Ｒ）－２－甲基－４－四氢吡喃氧基丁醛．用ＩＲ及１ＨＮＭＲ进行表征，这３种目标产物的全合成的光学产率均为８４．９％．
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| 关 键 词： | （R）－2－甲基－1，4－丁二醇及其衍生物；不对称反应；硼氢化－氧化反应 |
A NEW METHOD OF SYNTHESIS OF (R) 3 METHYL 1,4 BUTANEDIOL AND ITS DERIVATIVES |
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| Li Yan Pan Yijun Zhang Wanxuan Huang Jinxia Xu Zhanghuang. A NEW METHOD OF SYNTHESIS OF (R) 3 METHYL 1,4 BUTANEDIOL AND ITS DERIVATIVES[J]. Journal of Hubei University(Natural Science Edition), 1996, 0(3) |
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| Authors: | Li Yan Pan Yijun Zhang Wanxuan Huang Jinxia Xu Zhanghuang |
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| Abstract: | Chiral 3 methy 1,4 butanediol and its derivatives are the important intermediate of synthesis of chiral smectic liquid crystal polyesters and chiral natrual products with biological activity. In the paper, a new efficient route of (R) 3 methyl 1,4 butanediol and its two derivatives, 2 methyl 4 tetrapyranyloxy 1 butanol and 2 methyl 4 tetrapyranylbutanal, was described, and the target products were synthesized by employing asymmetric hydroboration oxidation improved. The optical yields of the tatol synthesis for the three target products are about 84 9% ee. |
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| Keywords: | R) 3 methyl 1 4 butanediol and its derivatives Asymmetric reaction Hydroboration oxidation |
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