| 多穗柯提取物的α-葡萄糖苷酶抑制活性筛选 |
| |
| 引用本文： | 方海莲,刘妹玲,李诗瑶,肖竹平. 多穗柯提取物的α-葡萄糖苷酶抑制活性筛选[J]. 吉首大学学报(自然科学版), 2020, 41(2): 54-57. DOI: 10.13438/j.cnki.jdzk.2020.02.012 |
| |
| 作者姓名： | 方海莲 刘妹玲 李诗瑶 肖竹平 |
| |
| 作者单位： | （吉首大学民族药解析与创制湖南省工程实验室，湖南 吉首 416000） |
| |
| 基金项目： | 湘西自治州科技计划;国家自然科学基金;吉首大学研究生科研创新项目 |
| |
| 摘 要： | 为了探究多穗柯不同提取物对α-葡萄糖苷酶的抑制活性，采用不同溶剂回流提取和不同极性剂溶剂萃取2种方法得到多穗柯提取液，分别建立体外α-葡萄糖苷酶抑制模型，对提取液进行活性筛选，分析提取物浓度与抑制活性的关系，筛选出抑制效果最佳的提取方法.结果表明，甲醇提取物（IC50=34.30 mg/L）和正丁醇萃取物（IC50=30.47 mg/L）的抑制效果更接近于阿卡波糖（IC50=25.26 mg/L）.
|
| 关 键 词： | 多穗柯 &alpha -葡萄糖苷酶 抑制剂 血糖 |
Inhibitory Activity Screening of Extract from Lithocarpus Polystachyus Rehd. Against α-Glucosidase |
| |
| FANG Hailian,LIU Meiling,LI Shiyao,XIAO Zhuping. Inhibitory Activity Screening of Extract from Lithocarpus Polystachyus Rehd. Against α-Glucosidase[J]. Journal of Jishou University(Natural Science Edition), 2020, 41(2): 54-57. DOI: 10.13438/j.cnki.jdzk.2020.02.012 |
| |
| Authors: | FANG Hailian LIU Meiling LI Shiyao XIAO Zhuping |
| |
| Affiliation: | (Hunan Engineering Laboratory for Analysis and Development of Ethnomedicine, Jishou University, Jishou 416000, Hunan China) |
| |
| Abstract: | The inhibitory activity of extract from Lithocarpus polystachyus Rehd. against α-glucosidase has been researched. The extract was obtained through reflux extraction with different solvents and leaching with different polar solvents. By establishing α-glucosidase inhibitory model in vitro, the activity of extracts from the leaf of Lithocarpus polystachyus Rehd. was screened, and the relationship between inhibitory activity and concentration of the extract was researched. Results show that inhibition effect of methanol extract (IC50=34.30 mg/L) and n-butanol extract (IC50=30.47 mg/L) was closer to that of acarbose (IC50=25.26 mg/L). |
| |
| Keywords: | Lithocarpus polystachyus Rehd. α-glucosidase inhibitor blood glucose |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《吉首大学学报(自然科学版)》浏览原始摘要信息 |
|
点击此处可从《吉首大学学报(自然科学版)》下载全文 |
