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| 高效的以腙为配体铜催化的C-N交叉偶联反应 | |
| 引用本文： | 张占金,唐旭静,李争宁,陈会英. 高效的以腙为配体铜催化的C-N交叉偶联反应[J]. 大连民族学院学报, 2017, 19(1): 14-20 |
| 作者姓名： | 张占金 唐旭静 李争宁 陈会英 |
| 作者单位： | 1.大连民族大学 生命科学学院,辽宁 大连 116605; 2.大连大学环境与化工学院,辽宁 大连 116600 |
| 摘 要： | 开发了一种温和、高效的以腙为配体的铜催化系统Cu2O/2-噻吩甲醛-N-甲基苯腙(4a)/Cs2CO3/DMSO,并在相对温和的条件下,将该系统用于催化胺与芳卤的交叉偶联反应,表现了良好的催化活性。交叉偶联反应的最大收率达到了80 %。实验表明,该类配体是稳定的、价廉的且可从市场上得到的原料,易于通过简单的方法进行制备。 |
| 关 键 词： | 胺 芳卤 腙 C-N交叉偶联 |
Highly Efficient Copper-Catalyzed C-N Cross Coupling Reaction Using Hydrazone as Ligand |
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| ZHANG Zhan-jin,TANG Xu-jing,LI Zheng-ning,CHEN Hui-ying. Highly Efficient Copper-Catalyzed C-N Cross Coupling Reaction Using Hydrazone as Ligand[J]. Journal of Dalian Nationalities University, 2017, 19(1): 14-20 | |
| Authors: | ZHANG Zhan-jin TANG Xu-jing LI Zheng-ning CHEN Hui-ying |
| Affiliation: | 1.School of Life Science, Dalian Minzu University, Dalian Liaoning 116605, China; 2.College of Environmental and Chemical Engineering, Dalian University, Dalian Liaoning 116600, China |
| Abstract: | A mild and highly efficient copper-catalyzed system, i.e, Cu2O/2-thiophenolaldehyde-N-methyl phenyl hydrazone (4a)/Cs2CO3/DMSO for cross coupling reaction of amines with aryl halides using hydrazone as ligand was developed and good catalytic activity was revealed. The reactions were carried out under relatively mild condition. The optimal yield reached to 80% for cross coupling reactions. It was showed that hydrazone ligands were stable, low-cost and easily prepared from inexpensive, commercially available starting materials using a simple, efficient method. |
| Keywords: | amine arylhalide hydrazone C-N cross coupling |
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