Maternal nodal and zebrafish embryogenesis |
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| Authors: | Bennett James T Stickney Heather L Choi Wen-Yee Ciruna Brian Talbot William S Schier Alexander F |
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| Affiliation: | Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA. |
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| Abstract: | In fish and amphibians, the dorsal axis is specified by the asymmetric localization of maternally provided components of the Wnt signalling pathway. Gore et al. suggest that the Nodal signal Squint (Sqt) is required as a maternally provided dorsal determinant in zebrafish. Here we test their proposal and show that the maternal activities of sqt and the related Nodal gene cyclops (cyc) are not required for dorsoventral patterning. |
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