| 青蒿素-β-环糊精包合物的制备及表征 |
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| 引用本文： | 谭清华,杨江静,唐艳辉,段友构.青蒿素-β-环糊精包合物的制备及表征[J].吉首大学学报(自然科学版),2013,34(4):72-76. |
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| 作者姓名： | 谭清华 杨江静 唐艳辉 段友构 |
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| 作者单位： | （吉首大学化学化工学院，湖南 吉首 416000） |
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| 基金项目： | 吉首大学研究性学习和创新性实验计划项目，湖南省教育厅资助项目，湖南省普通高等学校教改项目，吉首大学重点科研项目 |
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| 摘 要： | 研究青蒿素-β-环糊精包合物的制备与性质，通过相溶解度法、红外光谱(IR)对其包合物进行表征.结果表明，β-环糊精可增加青蒿素的溶解度；相溶解度法测定青蒿素与β-环糊精的包合常数为77.44 L/mol；IR检测到青蒿素的特征吸收峰，受包合物形成的影响其强度降低、峰形变宽、发生位移或消失等现象，青蒿素与β-环糊精可以形成稳定的包合物.
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| 关 键 词： | 青蒿素 &beta -环糊精 包合物 包合常数 红外光谱 |
Preparation and Characterization of Inclusion Complex Arteannuin with β-Cyclodextrin |
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| TAN Qing-hua
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YANG Jiang-jing
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TANG Yan-hui
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DUAN You-gou.Preparation and Characterization of Inclusion Complex Arteannuin with β-Cyclodextrin[J].Journal of Jishou University(Natural Science Edition),2013,34(4):72-76. |
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| Authors: | TAN Qing-hua YANG Jiang-jing TANG Yan-hui DUAN You-gou |
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| Institution: | (College of Chemistry and Chemical Engineering,Jishou University,Jishou 416000,Hunan China) |
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| Abstract: | The preparation and characterizations of the inclusion complex of arteannuin (ART) with β-cyclodextrin (β-CD) were investigated.The properties of arteannuin with β-cyclodextrin were characterized and analyzed by phase solubility analysis and infrared spectrography (IR).Results showed that β-cylcodextrin could increase the solubility of arteannuin;the inclusion constants of arteannuin with β-cylcodextrin (β-CD) was calculated as 77.44 L/mol;IR spectra showed that the intensity of a few characteristic absorption peak of ART decreased,the peak shape was widened and the displacement changed or disappeared under the influence of inclusion complex.It is concluded arteannuin and β-cylcodextrin can form stable inclusion complexes. |
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| Keywords: | arteannuin &beta -cyclodextrin inclusion complex inclusion constant infrared spectrum (IR) |
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