| Carmofur/PLA-PEG微球制备及其对包封率的影响 |
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| 引用本文： | 任杰,郁晓,任天斌,袁华. Carmofur/PLA-PEG微球制备及其对包封率的影响[J]. 同济大学学报(自然科学版), 2006, 34(1): 97-101 |
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| 作者姓名： | 任杰 郁晓 任天斌 袁华 |
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| 作者单位： | 同济大学,材料科学与工程学院,上海,200092;同济大学,纳米与生物高分子材料研究所,上海,200092 |
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| 基金项目： | 上海市纳米科技专项基金;同济大学校科研和教改项目 |
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| 摘 要： | 以开环聚合制备的聚乳酸-聚乙二醇（PLA-PEG）共聚物具有优良的生物相容性，广泛应用于药物载体．将其作为壁材用相分离法制备含抗癌药Carmofur的PLA-PEG微球，研究了共聚物质量浓度、油水体积比、油相和水相的温度、共聚物的特性粘数、表面活性剂的用量等因素对药物包封率的影响，并进行了体外药物释放的测试．
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| 关 键 词： | 聚乳酸-聚乙二醇 微球 相分离法 包封率 |
| 文章编号： | 0253-374X（2006）01-0097-05 |
| 收稿时间： | 2004-07-27 |
| 修稿时间： | 2004-07-27 |
Preparation and Characterization of Curmofar/PLA-PEG Microsphercs and the Effects on the Entrapment Efficiency |
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| REN Jie,YU Xiao,REN Tianbin,YUAN Hua. Preparation and Characterization of Curmofar/PLA-PEG Microsphercs and the Effects on the Entrapment Efficiency[J]. Journal of Tongji University(Natural Science), 2006, 34(1): 97-101 |
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| Authors: | REN Jie YU Xiao REN Tianbin YUAN Hua |
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| Affiliation: | 1. School of Material Science and Engineering, Tongji University, Shanghai 200092, China; 2. Institute of Nano- and Bio-Polymerie Materials, Tongji University, Shanghai 200092, China |
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| Abstract: | Carmofur-loaded poly-lactide-co-polyethylene glycol(PLA-PEG) nanoparticles was prepared by precipitation method.The average particle size and size distribution were measured by laser light scattering technique.The entrapment efficiency of Carmofur microspheres was measured by ultraviolet spectrophotometer.Experimental parameters such as O/W(the volume rate of oil/water),the concentration of polymer in oil phase,the temperature of water phase and the viscosity of polymer,the dosage of the Span-80 for the entrapment efficiency were studied.The drug release test of the microspheres was carried out in vitro. |
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| Keywords: | PLA-PEG copolymer microspheres phase precipitation entrapment efficiency |
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