| 常温下2-氨基-6-硫代-6H-噻喃酮-3-腈的合成 |
| |
| 引用本文： | 佟光进,相艳,朱晓彤.常温下2-氨基-6-硫代-6H-噻喃酮-3-腈的合成[J].徐州师范大学学报(自然科学版),2013(2):61-64. |
| |
| 作者姓名： | 佟光进 相艳 朱晓彤 |
| |
| 作者单位： | [1]江苏省徐州医药高等职业学校药学技术系,江苏徐州221116 [2]徐州医学院公共教育学院化学教研室,江苏徐州221004 |
| |
| 基金项目： | 国家自然科学基金青年项目（21102124） |
| |
| 摘 要： | 以苯基亚乙烯基丙二腈、CS2为起始原料,DMF为溶剂,碱性较弱的微量NaOH粉末作催化剂,常温下搅拌可以得到较高产率的硫代噻喃酮衍生物.该种方法能高效快捷地构建噻喃酮骨架,避免了强碱乙醇钠的使用,反应条件温和,底物范围良好,后处理方便.
|
| 关 键 词： | 苯基亚乙烯基丙二腈 CS2 硫代噻喃酮 |
The synthesis of 2-amino-6-thio-6H-thiapyrones-3-nitrile at room temperature |
| |
| Tong Guangjin,Xiang Yan,Zhu Xiaotong.The synthesis of 2-amino-6-thio-6H-thiapyrones-3-nitrile at room temperature[J].Journal of Xuzhou Normal University(Natural Science Edition),2013(2):61-64. |
| |
| Authors: | Tong Guangjin Xiang Yan Zhu Xiaotong |
| |
| Institution: | 1. Pharmaceutical Technology, Jiangsu Provincial Xuzhou Pharmaceutical Vocational College, Xuzhou 221116, Jiangsu, China ; 2. Department of Chemistry,Xuzhou Medical College,Xuzhou 221004,Jiangsu,China) |
| |
| Abstract: | A series of 2-amino-6-thio-6H-thiapyrones-3-nitriles have been synthesized through the domino reactions between 2-（1-arylethylidene）malononitriles and carbon disulfide in DMF, using sodium hydroxide as a base catalyst. These reactions can generate high yields of thio-thiapyrones derivatives at room temperature. This article developed a highly efficient and fast method to build thiapyrones skeleton. It has the advantages of mild reaction condition, good range of substrates, avoiding the use of strong alkali sodium ethoxide, and convenience of the post-processing. |
| |
| Keywords: | 2-（1-arylethylidene）malononitriles carbon disulfide thio-thiapyrones |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
