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Discovery of novel avermectins with unprecedented insecticidal activity |
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| Authors: | H. Mrozik P. Eskola B. O. Linn A. Lusi T. L. Shih M. Tischler F. S. Waksmunski M. J. Wyvratt N. J. Hilton T. E. Anderson J. R. Babu R. A. Dybas F. A. Preiser M. H. Fisher |
| Affiliation: | (1) Merck Sharp & Dohme Research Laboratories, 07065 Rahway, New Jersey, USA;(2) Present address: Boyce Thompson Institute for Plant Research at Cornell University, Tower Road, 14853-1801 Ithaca, N.Y., USA |
| Abstract: | Summary A new class of insecticidal and antiparasitic agents, 4 -amino-4 -deoxy avermectins, has been developed by chemical modification of avermectin B1. The most effective of these compounds are 1500-fold more potent than avermectin B1 (abamectin) against the beet armywormSpodoptera exigua and show similar potency against other lepidopteran larvae. |
| Keywords: | 4 |
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