Neuronal accumulation and metabolism of3H-1-norepinephrine in rat portal vein: Evidence in relation to possible uneven alpha receptor distribution |
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| Authors: | G S Takimoto A K Cho J A Bevan |
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| Institution: | (1) Department of Pharmacology and Brain Research Institute, University of California, The Center for the Health Sciences, 90024 Los Angeles, California, USA |
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| Abstract: | Summary The rate of accumulation and metabolism of3H-1-norepinephrine in the neuronal plexus of rat portal vein produces a small transmitter concentration gradient across the longitudinal smooth muscle layer which cannot account for the prejunctional supersensitivity observed and suggests localization of the alpha-adrenergic receptors adjacent to the nerve plexus.Acknowledgment. This work was supported by USPHS grant HE 8359 (JAB) and USPHS grant MH 23839 (AKC). |
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