Topische Bestimmung des zerebralen Angriffs von Reserpin (Serpasil)

Summary The impact of Reserpine (Serpasil) has been investigated by stimulating different parts of the rabbit's brain (Cortex, Diencephalon, Rhinencephalon,Subst. reticularis). Simultaneously the spontaneous brain activity and the electrically induced discharge have been recorded and studied in the cortex, the thalamus (Nucl. dors. med. andlat.), the rhinencephalon and theSubst. reticularis of the brain stem.Reserpine has a depressing influence on the diencephalo-cortical system. It raises the threshold of the afterdischarge induced by stimulation of the cortex and of the thalamus.Nevertheless the drug induces no electrographic sleep pattern. It maintains a steady electric pattern of alertness and increases the electrical ground activity of the rhinencephalon.Reserpine also depresses the spikes induced in the cortex and in the thalamus by stimulation of the pontobulbar reticular system. This effect is supposed to be due to a pharmacological action located at the thalamocortical level rather than in the bulbar segment of the arousal system.