| 牺牲局部、成就整体的细胞自噬——2016年度诺贝尔生理学或医学奖成果简介 |
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| 引用本文： | 杨娇,胡荣贵. 牺牲局部、成就整体的细胞自噬——2016年度诺贝尔生理学或医学奖成果简介[J]. 科技导报(北京), 2016, 34(24): 39-43. DOI: 10.3981/j.issn.1000-7857.2016.24.005 |
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| 作者姓名： | 杨娇 胡荣贵 |
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| 作者单位： | 中国科学院上海生物化学与细胞生物学研究所, 中国科学院分子细胞科学卓越研究中心, 上海 200031 |
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| 摘 要： | 自噬是一种细胞自身成分降解并回收利用的基本过程。日本科学家Yoshinori Ohsumi（大隅良典）因阐明细胞自噬的分子机制和生理功能而获得2016年度诺贝尔生理学或医学奖。这项工作不但为理解机体适应饥饿、感染免疫应答等诸多生化过程打开了一扇窗，也为治疗自噬相关疾病及开发针对自噬的潜在药物靶标奠定了基础。本文解读细胞自噬分子机制的科学背景及内涵，综述自噬相关研究的进展，并探讨其对人类健康的重大意义。
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| 关 键 词： | 2016年度诺贝尔生理学或医学奖 细胞凋亡 细胞自噬 |
| 收稿时间： | 2016-10-23 |
Mechanism of autophagy: Commentary on the 2016 Nobel Prize in Physiology or Medicine |
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| YANG Jiao,HU Ronggui. Mechanism of autophagy: Commentary on the 2016 Nobel Prize in Physiology or Medicine[J]. Science & Technology Review, 2016, 34(24): 39-43. DOI: 10.3981/j.issn.1000-7857.2016.24.005 |
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| Authors: | YANG Jiao HU Ronggui |
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| Affiliation: | Shanghai Institute of Biochemistry and Cell Biology;Center for Excellence in Molecular and Cell Sciences, Chinese Academy of Sciences, Shanghai 200031, China |
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| Abstract: | The 2016 Nobel Prize in Physiology or Medicine honors Japanese scientist, Yoshinori Ohsumi, whose original work has elucidated the mechanism and physiological function of autophagy. His work helped us understand many physiological processes, for example adaptation to starvation and immune response to infection, and opened a new avenue for the development of therapeutic strategies against autophagy-related maladies. Here we briefly introduce his work about autophagy, the significance of his findings to human health, and related research progress at home and abroad. |
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| Keywords: | 2016 Nobel Prize in Physiology or Medicine apoptosis autophagy |
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