放射治疗中自适应技术研究进展

 介绍自适应放射治疗方案的提出背景及其基本理念。通过分析离线自适应方案和在线自适应方案的应用,阐述了自适应放射治疗的基本实施方法及不同的实施方案特点和优劣。进一步综述了当前国内外一些相关研究的成果,着重介绍了其在鼻咽癌、宫颈癌、前列腺癌等方面的研究进展以及各种软硬件技术的可行性及效用。认为当前的研究成果已证明了自适应放射治疗技术在肿瘤放疗中的应用价值,未来该技术的发展方向应是进一步研究完善技术规范,从而推广其在临床中的应用。

Adaptive radiation technology in radiotherapy

Adaptive radiation therapy (ART) is a close-cycle radiation therapy using various measurements’feedback to modify the initial plan. It intends to improve radiation therapy by systematically control the variations during the course of treatment and use them to reoptimize the initial plan. In this process, beam field and delivery dose should be routinely customized to each individual patient so that they can achieve a much safer dose escalation. This paper introduces the background and basic concept of ART, and discusses the basic ART method, as well as their advantages and disadvantages by analyzing the application of off-line and on-line ART programs in recent years. Its application in nasopharyngeal carcinoma, cervical cancer, and prostate cancer is reviewed, and the feasibility and effectiveness of a variety of hardware and software technologies are discussed. The current research achievement has demonstrated the value of ART in tumor treatment. Future research direction may be oriented to improvement of its technical specifications and clinical application.