冷冻电子显微技术——2017年度诺贝尔化学奖成果简析

 2017年度诺贝尔化学奖授予瑞士洛桑大学的Jacques Dubochet、美国哥伦比亚大学的Joachim Frank和英国MRC分子生物学实验室的Richard Henderson 3位科学家。本文简要介绍冷冻电镜的发展历史、3位诺贝尔奖获得者在冷冻电镜技术发展过程中的贡献以及国际和国内的最新研究进展。

Cryo-electron microscopy:Commentary on the 2017 Nobel Prize in Chemistry

The 2017 Nobel Prize in Chemistry was awarded to Jacques Dubochet, Joachim Frank and Richard Henderson for their contributions to the development of cryo-electron microscopy (cryo-EM) in determining the solution structures of biomolecular assemblies. In this article, we briefly introduce the history of cryo-EM and comment on the essential roles these three scientists have played in realizing this cutting-edge technique. We also present a summary of recent research breakthroughs that were made by Chinese scientists.