脑组织液测量技术与研究现状

 脑组织液(ISF)是脑细胞生存微环境内最重要的组成要素,对中枢神经系统稳态的维持具有重要意义。由于以往研究手段与技术方法的限制,人们对ISF 的产生、代谢与引流过程的认识一直存在争议。近期,测量技术的进步为脑ISF 研究提供了全新的解剖和生理参数指标,辅以分子成像技术,脑ISF 的生理特性及其与其内的脑神经网络的关系研究已成为可能。本文在总结ISF 测量技术的基础上,对ISF 的来源、流动、引流途径等相关生理与病理研究进展进行综述。

Research progress for cerebral interstitial fluid

The interstitial fluid (ISF) in the brain parenchyma is one of the most important ingredients of the microenvironment of the nerve cells and plays an important role in homeostasis of the central neural system. Due to the limitation of the traditional technologies, the possible source, the flow and the drainage process of the ISF remain unclear in many respects. Recently, with the development of the molecular tracing imaging technology and related measurement methods, some new anatomical and physiological parameters of the ISF are identified to provide new insights into the mechanisms of the generation, the drainage of the ISF and its function and clinical applications. The development of technical methods also provide a foundation for the study of the relationship between the ISF and the connectomes. This paper reviews the source, the flow and the drainage of the ISF and its physiological and pathological significance.