| 基于活塞挤出的组织工程支架低温沉积制造工艺 |
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| 引用本文： | 金乐,熊卓,刘利,颜永年,张人佶.基于活塞挤出的组织工程支架低温沉积制造工艺[J].清华大学学报(自然科学版),2009(5). |
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| 作者姓名： | 金乐 熊卓 刘利 颜永年 张人佶 |
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| 作者单位： | 清华大学机械工程系; |
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| 基金项目： | 国家自然科学基金资助项目(50675108) |
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| 摘 要： | 快速成形(RP)工艺可实现个性化制造和可控的材料、结构组成,因此在组织工程中得到广泛应用。该文设计开发基于活塞挤出的材料喷头,对挤出工艺进行探讨与研究,提出采用压力自释放方案解决其流涎问题,并将其应用于低温沉积制造(LDM)工艺。实验表明,基于活塞挤出的LDM工艺可以成形组织工程支架,并且具有广泛的材料适应性,可成形多种生物材料,尤其可成形其他RP工艺难于成形的胶原材料。
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| 关 键 词： | 组织工程支架 低温沉积 活塞挤出喷头 胶原 |
Low temperature deposition based on piston-extrusion for fabricating tissue engineering scaffolds |
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| JIN Le,XIONG Zhuo,LIU Li,YAN Yongnian,ZHANG Renji.Low temperature deposition based on piston-extrusion for fabricating tissue engineering scaffolds[J].Journal of Tsinghua University(Science and Technology),2009(5). |
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| Authors: | JIN Le XIONG Zhuo LIU Li YAN Yongnian ZHANG Renji |
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| Institution: | Department of Mechanical Engineering;Tsinghua University;Beijing 100084;China |
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| Abstract: | Rapid prototyping(RP)processes are widely used in tissue engineering,to produce customized designs with good controllability of scaffold materials and structures.Paper describes a piston-extrusion nozzle for low-temperature deposition manufacturing(LDM)developed to form scaffolds.A pressure-release solution was developed to stop the leakage from the nozzle to improve scaffold quality.The process can form a wide range of materials including collagen which is hard to form by other RP processes. |
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| Keywords: | tissue engineering scaffold low temperature deposition piston-extrusion nozzle collagen |
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