| 用核糖体扫描模型预测翻译起始位点 |
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| 引用本文： | 刘利,李前忠. 用核糖体扫描模型预测翻译起始位点[J]. 内蒙古大学学报(自然科学版), 2007, 38(2): 173-180 |
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| 作者姓名： | 刘利 李前忠 |
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| 作者单位： | 内蒙古大学理工学院物理系,呼和浩特,010021;内蒙古大学理工学院物理系,呼和浩特,010021 |
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| 摘 要： | 真核生物翻译起始位点(TIS,translation initiation site)的正确预测对于基因的正确注释有着重大的意义.在真核生物中,翻译并不都是起始于第一个AUG密码子,还取决于AUG前后序列的信息.结合位置权重矩阵(PWM,position weight matrix)和开放阅读框架(ORF, open reading frame)的长度分布特征建立了简单的方法识别翻译起始位点,此方法能很好地区分上游AUG和TIS.对于脊椎动物以及人类的mRNA序列,运用核糖体扫描模型预测其翻译起始位点得到了很好的预测率.
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| 关 键 词： | 翻译起始位点 核糖体扫描模型 位置权重矩阵 开放阅读框架 |
| 文章编号： | 1000-1638(2007)02-0173-08 |
| 修稿时间： | 2006-07-25 |
Using Ribosome Scanning Model to Predict Translation Initiation Sites |
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| LIU Li,LI Qian-zhong. Using Ribosome Scanning Model to Predict Translation Initiation Sites[J]. Acta Scientiarum Naturalium Universitatis Neimongol, 2007, 38(2): 173-180 |
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| Authors: | LIU Li LI Qian-zhong |
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| Affiliation: | Department of Physics ,College of Sciences and Technology, Inner Mongolia University , Hohhot 010021, China |
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| Abstract: | The correct identification of the Translation Initiation Sites (TIS) in eukaryotes is an important issue for genome annotation.Translation in vertebrates does not always start at the first AUG in an mRNA, implying that context information also plays a role.Based on the position weight matrix(PWM) and length distribution of open reading frame(ORF),a simple method for predicting translation initiation sites is presented.It can identify TIS from upstream AUGs easily.By using of ribosome scanning model,high accuracy in vertebrates and human mRNA sequences is obtained. |
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| Keywords: | translation initiation site ribosome scanning model position weight matrix open reading frame |
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