| 2-甲基-4-丙酸甲酯苯酚的合成 |
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| 引用本文： | 孙灵,胡莹玉,李红斌,沈永嘉.2-甲基-4-丙酸甲酯苯酚的合成[J].华东理工大学学报(自然科学版),2000,26(4):409-411. |
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| 作者姓名： | 孙灵 胡莹玉 李红斌 沈永嘉 |
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| 作者单位： | 1. 华东理工大学精细化工研究所,上海,200237
2. 上海大学环境与建筑工程学院,上海,200072 |
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| 摘 要： | 邻甲酚与丙烯睛经Ｆｒｉｅｄｅｌ－Ｃｒａｆｔｓ反应得到了２－甲基－４－丙腈苯酚，再在甲醇中水解得到目标化合物。给出了该化合物及其中间体的质谱、核磁共振氢谱数据。讨论了不同催化剂用量对Ｆｒｉｅｄｅｌ－Ｃｒａｆｔｓ反应的影响以及不同反应介质对水解反应的影响。
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| 关 键 词： | 合成 邻甲酚 丙烯腈 2－甲基－4－丙酸甲酯苯酚 |
| 文章编号： | 1006-3080(2000)04-0409-03 |
| 修稿时间： | 1999-09-27 |
Synthesis of 2-Methyl-4-methyl Propionate-phenol |
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| SUN Ling,HU Ying-yu,LI Hong-bin,SHEN Yong-jia.Synthesis of 2-Methyl-4-methyl Propionate-phenol[J].Journal of East China University of Science and Technology,2000,26(4):409-411. |
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| Authors: | SUN Ling HU Ying-yu LI Hong-bin SHEN Yong-jia |
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| Institution: | SUN Ling
;(Institute of Fine Chemicals ECUST, Shanghai 200237, China);HU Ying-yu
;(School of Enviromental and Architectural Engineering, Shanghai University, Shanghai 200072, China);LI Hong-bin
,SHEN Yong-jia
;(Institute of Fine Chemicals ECUST, Shanghai 200237, China) |
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| Abstract: | Methyl 4 propylnitrilephenol was synthesized via Friedel Crafts reaction of o cresol with acrylonitrile in the presence of anhydrous aluminium chloride. The condensed product was hydrolyzed in a mixture of methanol and sulfuric acid medium to afford the title compound. Mass spectrometric and 1H NMR spectral data of the product and its intermediates were given. The effects of different volume of anhydrous alunimium chloride on the Friedel Crafts reaction and different medium on hydrolysis reaction were discussed. |
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| Keywords: | synthesis Friedel-Crafts reaction 2-methyl-4-propylnitrilephenol 2-methyl-4-methyl propionate-phenol |
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