In vitro enhancement of human platelet aggregation by somatostatin |
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| Authors: | P P Gazzaniga G Di Macco R La Mancusa A Oddi G Pappalardo F M Pulcinelli D Reggio |
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| Institution: | Department of Experimental Medicine, University of Rome La Sapienza, Italy. |
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| Abstract: | Very low concentrations of somatostatin (S-14) strongly potentiate the in vitro aggregation induced by collagen, ristocetin and arachidonic acid, but not that induced by ADP or epinephrine, in both human platelet rich plasmas and gel-filtered platelet preparations. Desensitization phenomena may be induced either by repeated addition of S-14 or long lasting contact between S-14 and platelets. |
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