典型地区汞污染效应及其粮食诱导大鼠c-jun表达

为探讨典型汞污染地区汞的生态影响、汞污染对当地居民健康的影响和危害评价以及汞神经毒性分子机制，对我国贵州万山汞矿环境介质和食物链进行了调查，并应用万山和清镇两地实验田生产粮食对大鼠进行暴露，结果发现，该矿区水土环境介质样品及农作物、植物和动物体中的汞含量，多数都超过了国家标准及对照地区，有的超出幅度很大；实地粮食能够显著诱导大鼠脑即早基因c-jun mRNA表达；即早基因c-jun参与了汞污染粮食对中枢神经系统损害的毒性过程。

The Ecological Effects of Mercury in Typical Mercury Contaminated Area and the Expression of c-jun Induced by Rice

In order to probe into the ecological effects of mercury in typical mercury contaminated area, and the influence and the assessment of the pollution on the health of local citizen, and the molecular mechanism of neurotoxicity of mercury, this paper studied the environmental medium and food chain in Wanshan mercury mining area. The rats were exposed to rice from Wanshan mercury mining and Qingzhen chemical plant respectively. The results show that the mercury content in the most media of water, soil and in the biomass of corn, plant and animas is higher than the national standard or the data from unpolluted area. The expression of immediately early gene c-jun mRNA in rat brain is induced significantly by mercury contaminated rice. The immediately early gene(c-jun) participates in the toxicity process of center nerve system injury by mercury contaminate rice.