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Immunohistochemical localization of glutamine synthetase in human liver
Authors:R Gebhardt  H Schmid  H Fitzke
Institution:1. Physiologisch-chemisches Institut, Universit?t Tübingen, Hoppe-Seyler-Str. 4, D-7400, Tübingen, (Federal Republic of Germany)
2. Pathologisches Institut, Universit?t Tübingen, Liebermeisterstr. 8, D-7400, Tübingen, (Federal Republic of Germany)
Abstract:Glutamine synthetase (GS) of human liver was recognized with a polyclonal antibody to pig brain GS, but failed to stain with an antibody against rat liver GS. Using the latter antibody GS of human liver was shown to be localized within small rings of 1 to 3 hepatocytes surrounding the terminal hepatic venules. This pattern was analogous to that seen in rat and mouse liver.
Keywords:Ammonia detoxification  enzyme distribution  glutamine synthetase  human liver  immunohistochemistry
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