Determination of DNA single-strand breaks by low-energy heavy ion and analysis of dose-effect curves |
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Authors: | Yanhua Du Shenghai Huang Zheng Tan Yingzhi Lin Guanying Qiu |
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Institution: | (1) College of Life Sciences, Wuhan University, 430072 Wuhan, China |
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Abstract: | Calf thymus DNA was exposed to low-energy heavy ions (N+) and60Co-γ-rays, and the dose-effect on DNA single-strand breaks (SSB) has been investigated. The results indicate that the dose-effect
curve by N+ irradiation is different from that of conventional ionizing radiation. While the curve from γ-irradiation follows exponential
type, the effect curve produced by N+ ion is of “saddle type”. The yield of DNASSB per dose unit per DNA unit remained at a certain level under different doses
of γ-rays. In contrast, the DNASSB at low dosage region of N+ showed an obvious peak before it decreased rapidly to a lower level. |
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Keywords: | ion implantation γ -rays “ saddle types” curve DNA single-strand breaks curve fitting |
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