Effects of vanadate on the activities of mice glucokinase and hexokinase |
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Authors: | Xu Ming-zhi Zhang Ai-zhen Li Xiang-rong Xu Wei Shen Ling-wei |
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Institution: | Department of Endocrinology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China. xu921@21cn.com |
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Abstract: | This study aimed at acquiring knowledge on the hypoglycemic mechanisms of sodium metavanadate (SMV) showed that the liver glucokinase and muscle hexokinase activities increased rapidly after oral SMV was given, and that the blood glucose level was correlated closely with the activities of the two enzymes but not with the insulin level; which indicated that SMV could improve the altered glucose phosphorylation in diabetic mice independently of stimulating insulin secretion. This was probably one of the mechanisms of hypoglycemic effects of SMV. |
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