| 基因表达的钙离子调控机制研究 |
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| 引用本文： | 朱春莲,张立辉.基因表达的钙离子调控机制研究[J].江汉大学学报(自然科学版),2008,36(4). |
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| 作者姓名： | 朱春莲 张立辉 |
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| 作者单位： | 江汉大学,物理与信息工程学院,武汉,430056 |
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| 摘 要： | 基于基因调节系统的动力学模型,利用数值模拟方法研究了Ca2+振荡对基因表达活性的影响.结果表明:细胞内Ca2+振荡能降低活化转录因子的有效钙阈值;转录因子的活性随Ca2+浓度平均水平增高而增大,但随着细胞内Ca2+振荡周期的增大而减小.
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| 关 键 词： | 转录因子 钙离子振荡调节 动力学模型 |
Study on Mechanism of Gene Expression Regulated by Ca2+ Oscillations |
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| ZHU Chun-lian,ZHANG Li-hui.Study on Mechanism of Gene Expression Regulated by Ca2+ Oscillations[J].Journal of Jianghan University:Natural Sciences,2008,36(4). |
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| Authors: | ZHU Chun-lian ZHANG Li-hui |
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| Abstract: | Based on one of the kinetic models for the genetic regulation system.The effects of Ca2 oscillations on the activation of gene expression are investigated by using of numerical simu-lation method.The results demonstrate that Ca2 oscillations decrease the effective Ca2 threshold for the activation of gene expression;the average activation of gene expression is increased with the in-crease of average amplitude of intracellular Ca2 oscillation,but decreased with the increase of period of intracellular Ca2 oscillation. |
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