| 1,4-二氢吡啶衍生物与CT DNA相互作用的电化学研究 |
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| 引用本文： | 徐飞,李静,杜江燕,王炳祥,陆天虹. 1,4-二氢吡啶衍生物与CT DNA相互作用的电化学研究[J]. 南京师大学报(自然科学版), 2005, 28(3): 56-60 |
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| 作者姓名： | 徐飞 李静 杜江燕 王炳祥 陆天虹 |
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| 作者单位： | 南京中医药大学药学院,210029,江苏,南京;南京师范大学化学与环境科学学院,210097,江苏,南京;南京师范大学化学与环境科学学院,210097,江苏,南京;中国科学院长春应用化学研究所,130022,吉林,长春 |
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| 基金项目： | 江苏省教育厅自然科学基金(02KJB150006)，国家“211”工程重点学科建设资助项目 |
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| 摘 要： | 用电化学方法研究了1,4-二氢吡啶衍生物（1,4-DHP）与小牛胸腺DNA（CT DNA）作用前后在玻碳电极上的电化学行为.结果表明,1,4-DHP在GC电极上的氧化峰峰电位（EPa）随着C-4取代基的吸电子能力增强而升高,氧化反应越来越难进行.1,4-DHP与CT DNA结合后,氧化峰峰电流降低和峰电位正移程度随着C-4取代基的空间位阻增大而减小.
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| 关 键 词： | 1 4-DHP CT-DNA 相互作用 电化学行为 |
| 文章编号： | 1001-4616(2005)03-0056-05 |
| 修稿时间： | 2005-03-10 |
Electrochemical Studies of Interaction Between 1,4-Dihydropyridine Derivatives and CT DNA |
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| Xu Fei,Li Jing,Du Jiangyan,Wang Bingxiang,Lu Tianhong. Electrochemical Studies of Interaction Between 1,4-Dihydropyridine Derivatives and CT DNA[J]. Journal of Nanjing Normal University(Natural Science Edition), 2005, 28(3): 56-60 |
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| Authors: | Xu Fei Li Jing Du Jiangyan Wang Bingxiang Lu Tianhong |
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| Affiliation: | Xu Fei~1,Li Jing~2,Du Jiangyan~2,Wang Bingxiang~2,Lu Tianhong~ |
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| Abstract: | The electrochemical behavior of the 1,4-Dihydropyridine Derivatives(1,4-DHP) on the GC electrode was studied by cyclic voltammetry in the absence and presence of calf thymus DNA(CT DNA).The results show that the potential of the oxidation peak of 1,4-DHP(E_(pa)) becomes more positive,and the oxidation process is more difficult with an increase in the electron-attractive ability of the substituent at the C-4 position.The oxidation peak current of 1,4-DHP is decreased and the peak position is shifted to the positive direction when bound with CT DNA,while the degree of these phenomena is decreased with the increase of the steric hindrance of the substituent at the C-4 position. |
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| Keywords: | 1 4-DHP CT-DNA interaction electrochemical behavior |
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