| 注射用头孢呋辛钠他唑巴坦钠制剂安全性研究 |
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| 引用本文： | 邢桂兰,谢学立,曾渝,符健. 注射用头孢呋辛钠他唑巴坦钠制剂安全性研究[J]. 海南大学学报(自然科学版), 2011, 29(2): 143-146 |
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| 作者姓名： | 邢桂兰 谢学立 曾渝 符健 |
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| 作者单位： | 海南医学院海南省药物安全性评价研究中心,海南海口,271101 |
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| 摘 要： | 为考察注射用头孢呋辛钠他唑巴坦钠(4∶1)制剂的安全性,分别进行豚鼠全身过敏性、家兔局部刺激性和家兔红细胞溶血性试验.结果显示,动物给药后未见明显溶血反应,家兔耳缘静脉和股四头肌未见明显刺激反应,豚鼠也无全身过敏反应.表明本品符合肌肉和静脉注射用药安全性要求.
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| 关 键 词： | 头孢呋辛钠他唑巴坦钠 局部刺激性 过敏性 动物 |
Safety Evaluation of Cefuroximetazobactam Sodium for Injection |
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| XING Gui-lan , XIE Xue-li , ZENG Yu , FU Jian. Safety Evaluation of Cefuroximetazobactam Sodium for Injection[J]. Natural Science Journal of Hainan University, 2011, 29(2): 143-146 |
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| Authors: | XING Gui-lan XIE Xue-li ZENG Yu FU Jian |
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| Affiliation: | (Drug Safety Evaluation ＆ Research Center of Hainan Province, Hainan Medical Uninversity, Haikou, 571101 ) |
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| Abstract: | To evaluate the safety of combinations of cefuroximetazobactam sodium according to ratio 4：1 for in- jection, the tests on guinea pig irritability, hemolysis, muscle and vascular stimulation of rabbit were performed. The results showed that the Cefhroximetazobactam （4：1 ） injection had no hypersensitive reaction on guinea pigs, no evidences of hemolyzation and aggregation on rabbit erythroeyte in vitro, and no obvious stimulatory effects on muscles and marginal ear veins of rabbit. （4：1 ） injection was safe for clinical application. These results suggested that the Cefuroximetazobactam |
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| Keywords: | cefuroximetazobactam sodium injections muscles and vascular stimulation hypersensitivity ani-mal |
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