| FAM105A通过caspase依赖性途径和Bcl-2家族诱导细胞凋亡 |
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| 引用本文： | 袁梦,赵永浩,王云姝,刘亦倩,张弦,许华曦,张云武. FAM105A通过caspase依赖性途径和Bcl-2家族诱导细胞凋亡[J]. 厦门大学学报(自然科学版), 2011, 50(6): 1065-1069 |
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| 作者姓名： | 袁梦 赵永浩 王云姝 刘亦倩 张弦 许华曦 张云武 |
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| 作者单位： | 厦门大学生物医学研究院,福建省神经退行性疾病与衰老研究重点实验室,福建厦门361005 |
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| 基金项目： | 国家自然科学基金项目，国家重点基础研究发展计划(973)前期研究专项项目，国家科技重大专项项目，福建省自然科学杰出青年基金项目 |
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| 摘 要： | 在多细胞有机体中,细胞凋亡对调节正常细胞活动和发育起着关键作用.对参与细胞凋亡的蛋白的鉴定及其机制的阐明具有重要意义.FAM 105 A是新发现的促凋亡基因,过表达会导致细胞凋亡.研究了FAM105A促进细胞凋亡的潜在机制,结果表明,在HEK293T细胞中过表达FAM105A会导致caspase-3和caspase-9的剪切/激活,同时伴随着多聚ADP-核糖聚合酶(poly ADP ribose polymerase,PARP)的切割/失活.此外,过表达FAM105A能诱导细胞色素c(Cyt c)从线粒体释放到胞质,促凋亡蛋白Bax的表达水平升高,而抗凋亡蛋白Bcl-2的表达水平下降.这些结果表明FAM105A诱导的细胞凋亡过程需要caspase依赖性途径和Bcl-2家族共同参与.
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| 关 键 词： | FAM105A 细胞凋亡 caspases 细胞色素c Bcl-2家族 |
The Apoptosis Induced by FAM105A Through Bcl-2 Family and Caspase Dependent Pathway |
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| YUAN Meng,ZHAO Yong-hao,WANG Yun-shu,LIU Yi-qian,ZHANG Xian,XU Hua-xi,ZHANG Yun-wu. The Apoptosis Induced by FAM105A Through Bcl-2 Family and Caspase Dependent Pathway[J]. Journal of Xiamen University(Natural Science), 2011, 50(6): 1065-1069 |
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| Authors: | YUAN Meng ZHAO Yong-hao WANG Yun-shu LIU Yi-qian ZHANG Xian XU Hua-xi ZHANG Yun-wu |
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| Affiliation: | YUAN Meng,ZHAO Yong-hao,WANG Yun-shu,LIU Yi-qian,ZHANG Xian,XU Hua-xi,ZHANG Yun-wu (Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research,Institute for Biomedical Research,Xiamen University,Xiamen 361005,China) |
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| Abstract: | Apoptosis plays a crucial role in mediating normal cellular activities and development in multicellular organisms.Characterization and mechanistic elucidation of proteins involved in apoptosis are important for understanding this process.FAM105A is a newly identified pro-apoptotic gene,whose overexpression results in cell apoptosis.However,the mechanism underlying FAM105A-mediated apoptosis remains elusive.In this study,it was found that overexpression of FAM105A in HEK293T cells induced cleavage/activation... |
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| Keywords: | FAM105A apoptosis caspases cytochrome c Bcl-2 families |
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