The effect of guanethidine treatment of testicular blood flow and testosterone production in rats |
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Authors: | J E Damber |
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Institution: | (1) Department of Urology and Andrology, University of Umeå, S-901 87 Umeå, Sweden |
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Abstract: | Summary Testicular blood flow was measured bymeans of Xenon-133 clearance in control rats and rats treated with guanethidine for 3 weeks. Plasma and testis testosterone concentrations were also measured, and the effect of hCG-treatment was examined. No difference in testicular blood flow between the control group and the guanethidinetreated group was found. However, in guanethidine-treated rats, plasma and testis testosterone concentrations after hCG-treatment were significantly decreased. The results may indicate that adrenergic nerves are involved in the regulation of Leydig cell function. |
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Keywords: | Guanethidine testis testicular blood flow hCG testosterone |
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