Endotoxemia and adrenaline-hyperreactive death in mice |
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| Authors: | K Kuratsuka Y Shimazaki I Funasaka Y Watabe |
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| Institution: | (1) Department of General Biologics Control, National Institute of Health, Kamiosaki 2-10-35, Shinagawa-ku, 141 Tokyo, (Japan) |
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| Abstract: | Summary Mice given i.v. a sublethal dose of endotoxin in advance died with shock-like symptoms on administration of sublethal adrenaline dose. The lethal adrenaline-hyperreaction induced by endotoxin appeared gradually within a few h, showed maximum response after several h and almost disappeared 24 h after endotoxin administration.Thanks are due to Dr Masami Kurokawa, Director of the Department, for his kind suggestions. |
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