| 静脉注射丙种球蛋白的溶液性质及稳定性研究 |
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| 引用本文： | 梁国眉,冯榕荫.静脉注射丙种球蛋白的溶液性质及稳定性研究[J].中山大学学报(自然科学版),1991,30(3):58-62. |
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| 作者姓名： | 梁国眉 冯榕荫 |
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| 作者单位： | 中山大学测试中心，中山大学测试中心，中山大学测试中心 |
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| 基金项目： | 广州市科委重点研究资助项目 |
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| 摘 要： | 采用小角激光光散射法(LALLS)结合粘度测定,分别对在不同pH和离子强度下的人血免疫丙种球蛋白(IgG)溶液性质进行了研究。结果表明,IgG在溶液中存在着不同的结构层次,包括单体、二聚体、聚集体、聚集堆积至沉淀析出。水溶性高分子聚乙烯基吡咯烷酮(PVP)的加入有利于保护丙球单体的稳定,起着防止其自身聚集的作用。
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| 关 键 词： | 小角激光光散射 静脉注射免疫丙球蛋白 聚乙烯基吡咯烷酮 聚集体 |
Studies on the Solution Properties and Stability of Immunoglobulin G for Intravenous |
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| Liang Gnomei,Fen Rongyin,Liang Xuewei Instrumentation Analysis and Research Center.Studies on the Solution Properties and Stability of Immunoglobulin G for Intravenous[J].Acta Scientiarum Naturalium Universitatis Sunyatseni,1991,30(3):58-62. |
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| Authors: | Liang Gnomei Fen Rongyin Liang Xuewei Instrumentation Analysis and Research Center |
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| Institution: | Liang Gnomei;Fen Rongyin;Liang Xuewei Instrumentation Analysis and Research Center |
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| Abstract: | The properties of Immunoglobulin G (IgG) solutions with different pH values and ion strengthes were investigated by means of low angle laser light scattering and viscosimetry. It was found that there were different Types of structure, including monomer molecules, dimers, aggregates and precipitates in the IgG solutions. The addition of water-soluble poly(vinyl- pyrrolidone) was effective for the stability of IgG monomer and prevented it from aggregation in the solution. |
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| Keywords: | low angle laser light scattering Immunoglobulin G poly(vinylpyrrolidone) aggregates |
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