| 普萘洛尔和美托洛尔的毛细管电泳富集分离研究 |
| |
| 引用本文： | 李敏,何友昭,淦五二,林祥钦,杨丽,瞿其曙.普萘洛尔和美托洛尔的毛细管电泳富集分离研究[J].中国科学技术大学学报,2001,31(5):596-599. |
| |
| 作者姓名： | 李敏 何友昭 淦五二 林祥钦 杨丽 瞿其曙 |
| |
| 作者单位： | 中国科学技术大学化学系, |
| |
| 基金项目： | 国家自然科学基金(29975026)资助项目 |
| |
| 摘 要： | 论文通过对药物普萘洛尔和美托洛尔的毛细管电泳分离，研究了场放大进样与瞬间等速电泳结合的毛细管电泳进样预富集方法，此方法采用大体积进样，使样品浓度富集两个数量级以上，有效地提高了毛细管电泳分析的灵敏度。
|
| 关 键 词： | 毛细管电泳 普萘洛尔 美托洛泉 富集 分离 场放大进样 瞬间等速电泳 药物测定 |
| 文章编号： | 0253-2778(2001)05-0596-04 |
| 修稿时间： | 2001年10月8日 |
Study on Pre-concentration and Separation of Propranolol and Metoprolol in Capillary Electrophoresis |
| |
| LI Min,HE You zhao,GAN Wu er,LIN Xiang qin,YANG Li,QU Qi shu.Study on Pre-concentration and Separation of Propranolol and Metoprolol in Capillary Electrophoresis[J].Journal of University of Science and Technology of China,2001,31(5):596-599. |
| |
| Authors: | LI Min HE You zhao GAN Wu er LIN Xiang qin YANG Li QU Qi shu |
| |
| Abstract: | The pre concentration and separation of propranolol and metoprolol with capillary electrophoresis were studied in this paper. The effects of some operation parameters, such buffer concentration and pH, sample medium concentration and time of field amplification and transient isotachophoresis injection on pre concentration and separation were investigeted in detail. In the optimum conditions, two medicines were separated completely. In addition, with a larger injection volume, the concentration enhancement factors were more than 2 orders of magnitude than those of the conventional method. |
| |
| Keywords: | capillary electrophoresis propranolol metoprolol pre concentration separation field amplification injection transient isotachophoresis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
