中药脑脊液药理学方法研究的概况

体外实验方法对于药理学研究至关重要,特别是在细胞、亚细胞、分子等水平进行深入的机制研究时,但此方法对于中药而言,存在许多问题。中药血清药理学作为一种新的体外试验方法,其实验结果被证明更加可信,与整体实验的相关性更好。随着中医药研究的不断深入以及中枢神经系统疾病防治的需要,中药复方有效成分是否能通过血脑屏障并产生效用已成为亟待解决的问题。中药脑脊液药理学方法的提出不仅为我们提供了一种科学的方法,更为中药复方作用的物质基础和作用机制研究带来了新思路。

Generalize the Methods of Study Cerebrospinal Fluid Pharmacology of Chinese Materia Medica

The method of experimental in vitro is important to study pharmacology, especially in in-depth study of mechanism with ceils, subcelluar or molecalar＇s leve｜,howere,there are many problems when research traditional Chinese medicine. Sero-pharmacology of Chinese materia medica, a new in vitro method,it＇s experimental results proved more credible and correlation in overall experimental. With the deepening of Chinese medicine research and the requirement for prevention and treatment of central nervous system＇s diseases, how through the blood-brain barrier with active ingredients of traditional Chinese medicine to make an effectiveness has become a serious problem. Proposed the method of cerebrospinal fluid pharmacology of Chinese materia medica not only provides us with a scientific method,bat also brought new ideas in study Material basis and mechanism of traditional Chinese medicine＇ s effectiveness.