| 牙齿矿化的低磷酸酯酶血症成因及对策 |
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| 引用本文： | 刘敏川.牙齿矿化的低磷酸酯酶血症成因及对策[J].吉首大学学报(自然科学版),2009,30(2):125-128. |
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| 作者姓名： | 刘敏川 |
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| 作者单位： | （四川大学华西口腔医学院儿童口腔科，四川 成都 610000） |
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| 摘 要： | 低磷酸酯酶血症是罕见的遗传性疾病，其典型特征有骨、牙齿矿化异常及血清、骨内碱性磷酸酯酶活性缺乏，临床表现多样.研究其分子发病机理、临床表现及治疗的最新进展，建议口腔医师接诊牙齿异常脱落患者应考虑其早期病史并做针对性诊断和治疗.
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| 关 键 词： | 低磷酸酯酶血症 组织非特异性碱性磷酸酯酶 基因突变 |
On Teeth Mineralization of Hypophosphatasia |
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| LIU Min-chuan.On Teeth Mineralization of Hypophosphatasia[J].Journal of Jishou University(Natural Science Edition),2009,30(2):125-128. |
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| Authors: | LIU Min-chuan |
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| Institution: | (Pediatric Dentistry of Huaxi Stomatological Hospital,Sichuan University,Chendu 610000,China) |
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| Abstract: | Hypophosphatasia is an inherited disorder rarely known to dentists in China.Defective bone and teeth mineralization,deficiency of serum and bone alkaline phosphatase are typical features.Symptoms are highly variable,and premature loss of the teeth is the clinical manifestation for dentists to deal in time.The molecular pathogenesis,symptoms and therapy have been reviewed in the paper. |
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| Keywords: | hypophosphatasia tissue non-specific alkaline phosphatase genetic mutation |
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