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Muscle lipofuscin content and satellite cell volume is increased after high altitude exposure in humans |
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| Authors: | M Martinelli R Winterhalder P Cerretelli H Howald H Hoppeler |
| Institution: | (1) Department of Anatomy, University of Bern, Bühlstrasse 26, CH-3000 Bern 9;(2) Department of Physiology, University of Geneva, CMU, 1 rue Michel Servet, CH-1211 Genève 4;(3) Ciba-Geigy AG, CH-4002 Basel, (Switzerland) |
| Abstract: | Summary Muscle ultrastructural changes during a typical expedition to the Himalayas were analyzed by taking muscle biopsies from seven climbers before and after their sojourn at high altitude (over 5000 m for 8 weeks). M. vastus lateralis samples were analyzed morphometrically from electron micrographs. A quantitative evaluation was made of lipofuscin, satellite cells and myonuclei. Significant increases of the volume densities of lipofuscin (+235%) and satellite cells (+215%) were observed. |
| Keywords: | Muscle morphometry human hypoxia lipofuscin satellite cell high altitude |
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