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GOODNESS-OF-FIT TEST WITH GENETIC BACKGROUND
Authors:WU Jihua XIE Minyu PENG Rong SUN Zhihua
Abstract:The chi-square test is a well-known goodness-of-fit test. It is available for arbitrary alternative hypothesis, particularly for a very general alternative. However, when the alternative is a "one-sided" hypothesis, which usually appears in genetic linkage analysis, the chi-square test does not use the information offered by the one-sided hypothesis. Therefore, it is possible that an appropriate one-sided test, which uses the information, will be better than the chi-square test. This paper gives such an efficient one-sided test. Monte Carlo simulation results show that it is more powerful than the chi-square test, and its power has been increased by 30 percent as compared with that of the chi-square test in most situations.
Keywords:Chi-square test  goodness-of-fit test  Monte Carlo simulation  
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