自发性静脉血栓栓塞症中实验室独立危险因素的新发现

发现与自发性静脉血栓栓塞症发生相关的实验室检测指标,对连续收集的48例既往无血栓病史的、首发的自发性静脉血栓栓塞症住院患者(以及48例未发生静脉血栓性疾病的住院患者做为对照组)进行实验室相关指标.包括:纤维蛋白原含量、白细胞计数、血小板计数和ABO血型的检测,并对这些实验室相关指标与自发性静脉血栓栓塞症的相关性分别进行单因素和多因素的统计学分析.结果单因素统计分析发现,纤维蛋白原含量和白细胞计数在血栓组与对照组间存在显著的差异(P＜0.05),而血小板计数和ABO血型在两组间差异无统计学意义(P＞0.05).对纤维蛋白原含量和白细胞计数与自发性静脉血栓栓塞症之间的相关性进行Logistic回归分析发现,纤维蛋白原含量和白细胞计数均为自发性静脉血栓栓塞症发生的独立危险因素,其OR值分别为纤维蛋白原含量2.17(95％ CI:1.306～3.608,p值=0.0028)和白细胞计数1.36(95％CI:1.074～1.719,p值=0.010 6).结论 纤维蛋白原含量和白细胞计数是自发性静脉血栓栓塞症的独立危险因素,通过与其他临床相关因素结合,可能有助于自发性静脉血栓栓塞症的预警和早期诊断.

The new findings of the independent risk factors of laboratory indexes of the idiopathic venous thromboembolism.

To find the laboratory-related indexes of idiopathic venous thromboembolism.We laboratory-related indexes(Fibriogen,White Blood Cell,Platelet,ABO blood type) for hospitalized patients of no history of thrombosis and the first idiopathic venous thromboembolism is examined.Univariate and multivariate statistical analysis of the correlation between these laboratory-related indexes and the idiopathic venous thromboembolism.It is resulted that through the univariate analysis,Fbg and WBC were higher in"thrombosis group"than in "the control group"(P<0.05),PLT and ABO blood type were not difference between "thrombosis group"and"the control group"(P>0.05).Through the Logistic regression model analysis,Fbg and WBC were the independent risk factors of the idiopathic venous thromboembolism(P<0.05),the odds ratio were 2.17,1.36.The overall partial regression coefficient of 95% confidence interval were 1.306~3.608,1.074~1.719.It is conclused that laboratory-related indexes(Fbg,WBC) are the independent risk factors of the idiopathic venous thromboembolism.By combination with the other clinically relevant factors,it may contribute to the early warning and early diagnosis of the idiopathic venous thromboembolism.