Differences in luteinizing hormone release stimulated in rat anterior pituitary cells by leukotriene C4 and by gonadotropin-releasing hormone in vitro |
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Authors: | A. Przylipiak L. Kiesel M. Przylipiak B. Runnebaum |
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Affiliation: | (1) Division of Gynecological Endocrinology, Department of Obstetrics and Gynecology, Voßstr 9, D-6900 Heidelberg, (Federal Republic of Germany) |
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Abstract: | Summary Continuous administration of leukotriene C4 (LTC4, 10–10 M) to superfused rat anterior pituitary cells increased LH release for 40 min only, whereas in a parallel experiment gonadotropin-releasing hormone (GnRH, 10–9 M) evoked a continuous increase in hormone secretion. In contrast to GnRH, LTC4 did not desensitize rat anterior pituitary cells. The secretory action resulting from the administration of LTC4 (10–10 M) was abolished for 40 min after previous stimulation. The results documented the dual action of LTC4 on LH exocytosis. |
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Keywords: | Leukotriene C4 luteinizing hormone gonadotropin releasing hormone desensitization rat anterior pituitary cells |
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