Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons |
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| Authors: | Parker J Alex Arango Margarita Abderrahmane Salima Lambert Emmanuel Tourette Cendrine Catoire Hélène Néri Christian |
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| Institution: | Institut National de la Santé et de la Recherche Médicale, Avenir Group, Laboratory of Genomic Biology, Centre Paul Broca, 75014 Paris, France. |
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| Abstract: | We report that Sir2 activation through increased sir-2.1 dosage or treatment with the sirtuin activator resveratrol specifically rescued early neuronal dysfunction phenotypes induced by mutant polyglutamines in transgenic Caenorhabditis elegans. These effects are dependent on daf-16 (Forkhead). Additionally, resveratrol rescued mutant polyglutamine-specific cell death in neuronal cells derived from HdhQ111 knock-in mice. We conclude that Sir2 activation may protect against mutant polyglutamines. |
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