Lack of pyrogenic tolerance transmission between brain and periphery in the rabbit |
| |
Authors: | W. Kozak D. Soszynski M. Szewczenko M. Bodurka |
| |
Affiliation: | (1) Department of Physiology, Medical University of Bydgoszcz, 24 Karlowicza Str., 85-092 Bydgoszcz, (Poland) |
| |
Abstract: | Summary Successive injections of lipopolysaccharide (LPS) either intravenously (i.v.) or intracerebroventricularly (i.c.v.) induced pyrogenic tolerance to LPS in rabbits. Tolerance was shown by a decrease of the magnitude of the fever response to repeated doses of LPS, irrespective of the route of pyrogen administration. A significantly greater and more dramatic decrease of the fever index, however, was observed in rabbits made tolerant to pyrogen given i.v. than when the pyrogen was given i.c.v. Transmission of the pyrogenic toleraance between brain and peripheral tissues, however, has not been ascertained. |
| |
Keywords: | Fever endotoxin tolerance brain periphery |
本文献已被 SpringerLink 等数据库收录! |
|