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Phosphorylation of isocitrate dehydrogenase as a demonstration of enhanced sensitivity in covalent regulation |
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| Authors: | D C LaPorte D E Koshland |
| Abstract: | The sensitivity to regulation of proteins undergoing covalent modification can be greatly increased when the substrates saturate the converter enzymes. This phenomenon, termed zero-order ultrasensitivity, has been found to occur in the reversible phosphorylation of isocitrate dehydrogenase. The possibility that this enhanced sensitivity is a common feature of covalent regulatory systems is discussed. |
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