| Subharmonic and ultraharmonic emissions based on the nonlinear oscillation of encapsulated microbubbles in ultrasound contrast agents |
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| 作者姓名： | GONG Yanjun ZHANG Dong GONG Xiufen |
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| 作者单位： | State Key Lab of Modern Acoustics, Institute of Acoustics, Nanjing University, Nanjing 210093, China |
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| 基金项目： | Acknowledgements This work was supported by the National Natural Science Foundation of China （Grant Nos. 10074033 and 10274032）, the National Natural Science Foundation of Jiangsu Province （BK2004081）, SRF for R0CS. SEM, and TWAS （No. 03-390）. |
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| 摘 要： | Subbarmonics or ultraharmonics provides better contrast-to-tissue ratio （CTR） than the fundamental or the second harmonics, having prospective application in medical diagnosis. In this paper, subharmonic and ultraharmonic emissions are theoretically studied through nonlinear oscillation of encapsulated bubbles. The optimized frequencies for emissions of the subharmonics and ultraharmonics are discussed. In addition, sound pressure dependences of the subharmonics and ultraharmonics are studied in theory as well as in measurement. Results reveal that the developments of both subharmonics and ultraharmonics have the same trend, i.e. occurrence, growth and saturation, but the generation of ultraharmonic is a little earlier than that of subharmonic.
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| 关 键 词： | 分频谐波 非线性振动 超频率音响 超谐波 UCA |
| 收稿时间： | 2005-05-30 |
| 修稿时间： | 2005-05-302005-06-17 |
Subharmonic and ultraharmonic emissions based on the nonlinear oscillation of encapsulated microbubbles in ultrasound contrast agents |
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| GONG Yanjun ZHANG Dong GONG Xiufen.Subharmonic and ultraharmonic emissions based on the nonlinear oscillation of encapsulated microbubbles in ultrasound contrast agents[J].Chinese Science Bulletin,2005,50(18):1975-1978. |
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| Authors: | Yanjun Gong Dong Zhang Xiufen Gong |
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| Institution: | GONG Yanjun, ZHANG Dong & GONG Xiufen State Key Lab of Modern Acoustics, Institute of Acoustics, Nanjing University, Nanjing 210093, China |
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| Abstract: | Subharmonics or ultraharmonics provides better contrast-to-tissue ratio (CTR) than the fundamental or the second harmonics, having prospective application in medical diagnosis. In this paper, subharmonic and ultra-harmonic emissions are theoretically studied through nonlinear oscillation of encapsulated bubbles. The optimized frequencies for emissions of the subharmonics and ultra-harmonics are discussed. In addition, sound pressure de-pendences of the subharmonics and ultraharmonics are studied in theory as well as in measurement. Results reveal that the developments of both subharmonics and ultrahar-monics have the same trend, i.e. occurrence, growth and saturation, but the generation of ultraharmonic is a little earlier than that of subharmonic. |
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| Keywords: | ultrasound contrast agent subharmonic ultraharmonic |
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