基于脑涨落图和抑郁评分系统评价中医综合治疗抑郁症的疗效

以DEP患者作为研究对象，利用脑涨落图仪（EFG）的客观检查方法及DEP现代医学评分系统，评价解郁合欢汤+五行音乐疗法的中医综合治疗方式对DEP的疗效。指标包括EFG检测大脑神经递质相对功率值、汉密尔顿抑郁量表（HAMD）以及蒙哥马利抑郁评定量表（MADRS）。EFG结果显示，患者治疗后脑内γ-氨基丁酸的相对功率值较治疗前显著降低（P<0.001），去甲肾上腺素（P<0.001）、多巴胺相对功率值（P<0.001）较治疗前显著提高，患者治疗后的HAMD(P<0.001)、MADRS(P<0.001)较治疗前显著降低。说明中医综合疗法对DEP的疗效确切，可通过对大脑神经递质的调节作用而发挥抗抑郁疗效。

Efficacy evaluation of comprehensive traditional Chinese medicine treatment on depression using the encephaloflocturograp and depression scoring system

Depression (DEP) has become the second greatest threat to human health. In order to evaluate the efficacy of traditional Chinese medicine comprehensive therapy (Jieyu Hehuan Decoction + five element music therapy) on DEP, DEP patients were enrolled and the objective examination of encephaloflocturograph (EFG) and the DEP scoring system were adopted in this study. The indexes include the relative power of brain neurotransmitter based on EFG, Hamilton Depression Scale (HAMD) and Montgomery Asberg Depression Rating Scale (MADRS). The results show that the relative power of γ -Aminobutyric acid decreases (P<0.001) while the relative power of dopamine (P<0.001) and norepinephrine (P<0.001) increase after the therapy, as well as the HAMD (P<0.001) and MADRS (P<0.001). It suggests that the traditional Chinese medicine comprehensive therapy has the proved efficacy on DEP, which produces the anti-DEP effect through the regulation of brain neurotransmitters.