Actin-based organelle movement |
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Authors: | V R Simon L A Pon |
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Institution: | (1) Department of Anatomy and Cell Biology, Columbia University, 630 W. 168th Street, P&S 12-425, 10032 New York, New York, USA |
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Abstract: | Evidence for actin-dependent organelle movement was first obtained from studies of cytoplasmic streaming in plants. These studies, together with cell-free organelle motility studies and biophysical analyses of muscle myosin, support a model whereby organelle-associated motor molecules utilize the energy of adenosine triphosphate binding and hydrolysis to drive movement along F-actin tracks Recent studies indicate that this mechanism for organelle movement may be responsible for organelle and vesicle movement during secretion, endocytosis and mitochondrial inheritance in a variety of eukaryotes. |
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Keywords: | Actin myosin motor molecules secretion endocytosis mitochondria organelle inheritance |
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