Inactivation of sarin and soman by cyclodextrins in vitro |
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Authors: | B Désiré S Saint-André |
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Institution: | (1) Division de Chimie et Pharmacologie, Centre de Recherches du Service de Santé des Armées, 108 boulevard Pinel, F-69275 Lyon Cedex 03, (France) |
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Abstract: | Summary Cyclodextrins catalyzed the inactivation of sarin and soman but did not inactivate tabun and VX. Furthermore, sarin and soman showed greater affinity for -cyclodextrin than for - or -cyclodextrins. Thus -cyclodextrin appears to be an attractive starting material for the preparation of a catalyst able to inactivate sarin and soman more effectively. Such a catalyst might contribute to improving the therapy of poisoning caused by these two nerve agents. |
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Keywords: | Nerve agents sarin soman tabun VX cyclodextrin |
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