Effect on non-steroidal anti-inflammatory drugs on Moloney sarcoma virus inoculated mice |
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Authors: | Anna D. Inglot Emilia Oleszak |
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Affiliation: | (1) Laboratory of Tumor Viruses, Department of Tumor Immunology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroc aw, (Poland) |
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Abstract: | Summary Chronic administration of phenylbutazone, flufenamic acid and a new, potent non-steroidal anti-inflammatory agent ITF (3-methyl-5-benzoyl-amino-isothiazole-4-carboxy-p-ethoxyphenylamine) to BALB/c mice inoculated with a Moloney sarcoma virus resulted in a stimulation of tumor growth and increased severity of disease. This treatment, however, had no effect on the spontaneous regression of tumors. Indomethacin in a dose of 5.0 or 2.5 mg per kg suppressed the MSV-induced tumor growth, but this effect was apparently connected with the high toxicity of this drug for mice. |
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