| HPLC-MSMS法快速鉴定Z/E马来酸桂哌奇特异构体 |
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| 引用本文： | 陈俊苗,朱登勇,王少敏,张凯,李翠萍,刘宏民.HPLC-MSMS法快速鉴定Z/E马来酸桂哌奇特异构体[J].郑州大学学报(自然科学版),2012(3):94-96. |
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| 作者姓名： | 陈俊苗 朱登勇 王少敏 张凯 李翠萍 刘宏民 |
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| 作者单位： | [1]郑州大学化学与分子工程学院,河南郑州450052 [2]郑州大学药学院,河南郑州450001 |
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| 基金项目： | 郑州大学211工程重点项目 |
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| 摘 要： | 首次采用高效液相色谱串联质谱技术建立了快速鉴定E型马来酸桂哌奇特原料药中Z型异构体杂质的新方法.以20%乙腈、80%乙酸铵缓冲溶液（pH=4.0）为流动相,通过高分辨电喷雾串联质谱在线检测,获得相关的色谱和质谱信息.本法能在无对照品情况下,快速准确地分离鉴定马来酸桂哌奇特原料中的Z/E异构体.
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| 关 键 词： | HPLC-MSMS 马来酸桂哌奇特 Z E异构体 |
Fast Identification of Z/E Cinepazide Maleate by HPLC-MSMS |
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| CHEN Jun-miao,ZHU Deng-yong,WANG Shao-min,ZHANG Kai,LI Cui-ping,LIU Hong-min.Fast Identification of Z/E Cinepazide Maleate by HPLC-MSMS[J].Journal of Zhengzhou University (Natural Science),2012(3):94-96. |
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| Authors: | CHEN Jun-miao ZHU Deng-yong WANG Shao-min ZHANG Kai LI Cui-ping LIU Hong-min |
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| Institution: | 1.College Chemsitry and Molecular Engineering,Zhengzhou University,Zhengzhou 450052,China; 2.School of Pharmaceutical Science,Zhengzhou University,Zhengzhou 450001,China) |
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| Abstract: | A new method for identifying Z isomer impurity from E cinepazide maleate bulk drug was established by HPLC-MSMS firstly.The mobile phase was acetonitrile 20% and ammonium acetate buffer solution 80%（pH=4.0）,and the eluent was detected by HPLC-MSMS.The method was quick and accurate in separating and identifying the Z isomeric impurity in raw drug material of E cinepazide maleate without control. |
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| Keywords: | HPLC-MSMS cinepazide maleate Z/E isomers |
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